Vitamin D genetic risk scores in multiple sclerosis

• DOI: 10.1007/s00415-022-11466-4
• Publication Date: 2022-11-05T10:08:47Z
• Authors: Ashvin Kuri; Nicola Vickaryous; Amine Awad; Benjamin Meir Jacobs; Ruth Dobson
• Keywords: Multiple sclerosis; 0301 basic medicine; 03 medical and health sciences; Original Communication; Multiple Sclerosis; Risk Factors; Dietary Supplements; Humans; Vitamin D; Vitamin D Deficiency; Genetic risk score; 3. Good health

Low serum 25(OH)D3 (vD) is an environmental risk factor for multiple sclerosis (MS). Lower vD levels during early disease may be associated with long-term disability. Determinants of in healthy individuals include supplementation behaviour and genetic factors. These determinants have been less well studied people MS (pwMS).We developed a vD-weighted score (GRS) validated this 373,357 UK Biobank participants without MS. We measured genotyped six vD-associated SNPs (rs12785878, rs10741657, rs17216707, rs10745742, rs8018720, rs2282679) cohort pwMS (n = 315) age geographically matched controls 232). then assessed predictors concentration cohort.The GRS was strongly status the (p < 2 × 10-16). supplementation, having MS, lower BMI, increased dose were higher (false discovery rate, FDR 5%). In multivariable models adjusting age, sex, status, level 0.004), but not those who supplemented 0.47).Our findings suggest that major determinant pwMS, playing far smaller role.