Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort

• DOI: 10.1007/s00415-023-12148-5
• Publication Date: 2024-01-09T18:01:41Z
• Authors: Augusto J. Mendes; Federica Ribaldi; Aurelien Lathuiliere; Nicholas J. Ashton; Shorena Janelidze; Henrik Zetterberg; Max Scheffler; Frédéric Assal; Valentina Garibotto; Kaj Blennow; Oskar Hansson; Giovanni B. Frisoni
• Keywords: Memory clinic; Neuroradiology

Abstract Background and objective Phosphorylated tau ( p -tau) 217 has recently received attention because it seems more reliable than other -tau variants for identifying Alzheimer’s disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma CSF -tau217 with -tau181 -tau231 in a memory clinic cohort. Methods The study included 114 participants (CU = 33; MCI 67; Dementia 14). were correlated versus continuous measures amyloid (A) (T)-PET. phospho-epitopes assessed through: (i) effect sizes δ ) between A ± T groups; (ii) receiver operating characteristic (ROC) analyses A-PET T-PET. Results correlations both T-PET r range 0.64–0.83) stronger those 0.44–0.79) 0.46–0.76). Plasma showed significantly higher differences biomarker groups : 0.55–0.96; 0.51–0.67; 0.53–0.71); ROC curves identify positivity (AUC average 0.96; 0.76; 0.79). On hand, 0.95) did not reveal significant AUC 0.88) 0.89). Discussion demonstrated better performance identification AD pathology clinical phenotypes comparison Furthermore, had comparable CSF. Our findings suggest potential diagnosis screening AD, which could allow decreased use invasive biomarkers future.