Burden of disease in Lambert-Eaton myasthenic syndrome: taking the patient’s perspective

• DOI: 10.1007/s00415-024-12206-6
• Publication Date: 2024-02-29T07:02:15Z
• Authors: Sophie Lehnerer; Meret Herdick; Regina Stegherr; Lea Gerischer; Frauke Stascheit; Maike Stein; Philipp Mergenthaler; Sarah Hoffmann; Andreas Meisel
• Keywords: Depression; Hyporeflexia; Lambert-Eaton myasthenic syndrome

Abstract Background Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune-mediated neuromuscular disorder leading to muscle weakness, autonomic dysregulation and hyporeflexia. Psychosocial well-being affected. Previously, we assessed burden of disease for Myasthenia gravis (MG). Here, aim elucidate by comparing health-related quality life (HRQoL) patients with LEMS the general population (genP) as well MG patients. Methods A questionnaire-based survey included sociodemographic clinical data along standardized questionnaires, e.g. Short Form Health (SF-36). HRQoL was evaluated through matched-pairs analyses. Participants from a health served control group. Results 46 matched age gender were compared 92 controls genP cohort participants showed lower levels physical functioning (SF-36 mean 34.2 SD 28.6) (mean 78.6 21.1) 61.3 31.8). mental sub-scores 62.7 20.2, vs. 75.7 15.1) 66.0 18.). Depression, anxiety fatigue prevalent. Female gender, low income, activities daily living, symptoms depression, associated in LEMS. Discussion pair-analysis. The includes economic social aspects emotional well-being. Trial Registration Information drks.de: DRKS00024527, submitted: February 02, 2021, https://drks.de/search/en/trial/DRKS00024527 .