Effects of occupational exposure to 1,4-dichlorobenzene on hematologic, kidney, and liver functions

Adult Male 0301 basic medicine 1 Taiwan 610 Urine analysis Chlorobenzenes Kidney Blood Urea Nitrogen Leukocyte Count Young Adult 03 medical and health sciences Occupational Exposure Humans Alanine Transaminase Occupational exposure Middle Aged 620 3. Good health Health effect Cross-Sectional Studies Liver Insect Repellents Female 4-Dichlorobenzene Chlorophenols
DOI: 10.1007/s00420-009-0398-5 Publication Date: 2009-02-26T10:14:22Z
ABSTRACT
To investigate the effects of 1,4-dichlorobenzene (1,4-DCB) on kidney, liver, and hematological functions of workers in insect repellent factories in Taiwan.A cross-sectional study was performed comparing 46 exposed workers and 29 non-exposed workers. Health information was collected using questionnaires and biochemical tests. The concentration of urinary 2,5-dichlorophenol (2,5-DCP), the major metabolite of 1,4-DCB, was analyzed by gas chromatography with electron-capture detection.Urinary 2,5-DCP concentration, white blood cell (WBC) count, and serum alanine aminotransferase (ALT) level were higher in exposed workers than in non-exposed ones (P < 0.05). Furthermore, the WBC count and ALT level were significantly correlated with the concentration of 2,5-DCP in urine (P < 0.05). The blood urea nitrogen was significantly higher in on-site exposed workers (P < 0.05). Urinary 2,5-DCP concentration was significantly lower in workers who wore personal protective equipment (PPE) during work than in those who did not (P < 0.05).The higher urinary 2,5-DCP concentration in exposed (105.38 μg/L) than non-exposed (1.08 μg/L) workers suggests that 1,4-DCB exposure may increase the 2,5-DCP concentration in urine. Moreover, exposure to 1,4-DCB may also increase WBC count and ALT activity, and PPE may protect workers from 1,4-DCB exposure.
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