Intradialytic cycling does not exacerbate microparticles or circulating markers of systemic inflammation in haemodialysis patients

• DOI: 10.1007/s00421-021-04846-7
• Publication Date: 2021-12-02T09:02:32Z
• Authors: Patrick J. Highton; Daniel S. March; Darren R. Churchward; Charlotte E. Gran...; Hannah M. L. Young; Matthew P. M. Gra...; Seila Estruel; Naomi Martin; Nigel J. Brunskill; Alice C. Smith; James O. Burton; Nicolette C. Bishop
• Keywords: Inflammation; Male; Middle Aged; Exercise Therapy; 3. Good health; 03 medical and health sciences; Phenotype; 0302 clinical medicine; Cell-Derived Microparticles; Renal Dialysis; Humans; Kidney Failure, Chronic; Original Article; Biomarkers

Abstract Purpose Patients receiving haemodialysis (HD) display elevated circulating microparticle (MP) concentration, tissue factor (TF) expression and markers of systemic inflammation, though regular intradialytic cycling (IDC) may have a therapeutic effect. This study investigated the impact regular, moderate-intensity IDC on MPs inflammatory in unit-based HD patients. Methods were cluster-randomised to intervention ( n = 20, age: 51.4 ± 18.1 years, body mass: 77.6 18.3 kg, mean SD) or no-exercise control 56.8 14.0 80.5 26.5 kg). Intervention participants completed 30 min moderate intensity (rating perceived exertion [RPE] 12–14) IDC, thrice weekly for 6 months. Pre-dialysis venous blood samples obtained at 0, 3 Circulating MP phenotypes, cytokines, chemokine TF quantified using flow cytometry cytometric bead array assays. Results Despite high exercise compliance (82%), no IDC-dependent effects observed any MP, cytokine measure p ≥ 0.051, η ρ 2 ≤ 0.399) other than TNF-α 0.001, 0.186), significance was revealed upon post hoc analysis. Conclusion Six months had effect MPs, cytokines chemokines. suggests that did not exacerbate thrombotic status, further functional assays are required confirm this. Trial registration ISRCTN1129707, prospectively registered 05/03/2015.