Tumour stage and resection margin status are independent survival factors following partial pancreatoduodenectomy for duodenal adenocarcinoma

• DOI: 10.1007/s00423-019-01779-w
• Publication Date: 2019-04-10T19:14:41Z
• Authors: Kulbir Mann; T. Gilbert; S. Cicconi; R. Jackson; P. Whelan; F. Campbell; C. Halloran; J. Neoptolemos; P. Ghaneh
• Keywords: Duodenal cancer; Resection margin; Gastric Outlet Obstruction; Univariate analysis

There is limited published evidence on duodenal carcinoma due to its rarity. This study aimed evaluate gastric outlet obstruction and obstructive jaundice along with pathological variables as survival factors in patients adenocarcinoma following resection. Survival factor analysis was undertaken undergoing cancer surgery from 1997 2015 a single centre. were 57 of whom 18 had 14 jaundice. Fifty-three partial pancreatoduodenectomy four palliative bypass. Perioperative mortality morbidity 4% (2/53) 47% (25/53) respectively resected patients. With median (95% confidence interval, CI) follow-up 72 (57–86) months, overall recurrence-free 38 months CI 28–113) 27 18–83) respectively. The 1 3-year rates 84% 74–95) 52% 39–69) Median 19 vs 53 those without (p = 0.026) 28 0.611). Univariate revealed that tumour stage, resection margin status, pre-operative albumin age associated poorer but multivariate confirmed only stage status be significant. Whereas appeared an important pancreatoduodenectomy, showed the key independent factors. Further multicentre studies are required elucidate further characteristics develop neoadjuvant/adjuvant management strategies.