Expression of phosphate and calcium transporters and their regulators in parotid glands of mice

• DOI: 10.1007/s00424-022-02764-x
• Publication Date: 2022-10-24T01:03:04Z
• Authors: Seraina O. Moser; Betül Haykir; Catharina J. Küng; Carla Bettoni; Nati Hernando; Carsten A. Wagner
• Keywords: Transcellular; Paracellular transport; Homeostasis; Hypophosphatemia; TRPV6

Abstract The concentration of inorganic phosphate (Pi) in plasma is under hormonal control, with deviations from normal values promptly corrected to avoid hyper- or hypophosphatemia. Major regulators include parathyroid hormone (PTH), fibroblast growth factor 23 (FGF-23), and active vitamin D 3 (calcitriol). This control achieved by mechanisms largely dependent on regulating intestinal absorption renal excretion, whose combined actions stabilise Pi levels at around 1–2 mM. Instead, concentrations up 13 40 mM have been measured saliva humans ruminants, respectively, suggesting that salivary glands the capacity concentrate Pi. Here we analysed transcriptome parotid glands, ileum, kidneys mice, investigate their potential differences regarding expression genes responsible for epithelial transport as well known regulators. Given Ca 2+ homeostasis are tightly connected, involved was also included. In addition, studied effect treatment three major glands. We found equipped preferentially Slc20 rather than Slc34 Na + /Pi cotransporters, suited through transcellular paracellular route targets PTH regulation.