Mantle cell lymphoma with partial involvement of the mantle zone: an early infiltration pattern of mantle cell lymphoma?

• DOI: 10.1007/s00428-008-0621-x
• Publication Date: 2008-08-11T05:42:26Z
• Authors: Assia Bassarova; Anne Tierens; Grete Fossum Laur...; Alexander Fosså; Jan Delabie
• Keywords: Mantle zone; Follicular hyperplasia; Lymph node biopsy; Follicular lymphoma

Most patients with mantle cell lymphoma present a diffuse or nodular infiltration of the involved organs at diagnosis. We two rare morphological variant, displaying partial involvement zone. Patient 1 presented an enlarged inguinal lymph node, which showed marked follicular hyperplasia singly spread Cyclin D1+ small lymphoid cells in zones. An additional node biopsy taken 3 months later same pattern. 2 classical bone marrow and gastro-intestinal involvement. However, revision appendectomy specimen 4 years earlier pronounced Mantle zone has rarely been reported many represent early manifestation lymphoma. Our cases also illustrate that inclusion anti-cyclin D1 antibody diagnostic panel antibodies to study unexplained hyperplasia, might be advised.