Normative biometry of the fetal brain using magnetic resonance imaging

• DOI: 10.1007/s00429-016-1342-6
• Publication Date: 2016-11-24T10:11:50Z
• Authors: Vanessa Kyriakopo...; Deniz Vatansever; Alice Davidson; Prachi Patkee; Samia Elkommos; Andrew Chew; Miriam Martinez-B...; Bibbi Hagberg; Mellisa Damodaram; Joanna Allsop; Matt Fox; Joseph V. Hajnal; Mary A. Rutherford
• Keywords: Histology; Biometry; Neuroscience(all); 610; Brain; Gestational Age; Brain development; Magnetic Resonance Imaging; Ultrasonography, Prenatal; 3. Good health; 03 medical and health sciences; Magnetic resonance imaging; Fetus; 0302 clinical medicine; Pregnancy; Image Processing, Computer-Assisted; Humans; Original Article; Female; Anatomy; Centiles

The fetal brain shows accelerated growth in the latter half of gestation, and these changes can be captured by 2D 3D biometry measurements. aim this study was to quantify normal fetuses using Magnetic Resonance Imaging (MRI) produce reference data a freely available centile calculator ( https://www.developingbrain.co.uk/fetalcentiles/ ). A total 127 MRI examinations (1.5 T) with appearance (21–38 gestational weeks) were included study. biometric parameters measured from slice-to-volume reconstructed images, including measurements supratentorial tissue, lateral ventricles, cortex, cerebellum extra-cerebral CSF biparietal diameter fronto-occipital length, skull occipitofrontal diameter, head circumference, transverse cerebellar CSF, ventricular atrial vermis height, width, area. Centiles constructed for each measurement. All participants invited developmental follow-up. measurements, except showed significant positive correlation age. There sex effect on left volumes degree asymmetry. 5th, 50th, 95th centiles produced. Developmental follow-up 73.1% cases [mean chronological age 27.4 (±10.2) months]. We present normative charts at 21–38 weeks. Developing trajectories will aid better understanding subsequently deviations typical development high-risk pregnancies or following premature delivery.