Mitral cell development in the olfactory bulb of sharks: evidences of a conserved pattern of glutamatergic neurogenesis

• DOI: 10.1007/s00429-019-01906-9
• Publication Date: 2019-06-15T12:02:48Z
• Authors: A. Docampo-Seara; M. Lanoizelet; R. Lagadec; S. Mazan; E. Candal; M. A. Rodríguez
• Keywords: PAX6; Cell fate determination

In mammals, the development of olfactory bulb (OB) relies in part on expression transcription factors involved specifications/differentiation glutamatergic cells. a previous study from our group, high molecular similarity was reported between mammals and cartilaginous fishes regarding neurogenic mechanisms underlying cells telencephalon. However, information about transcriptional program operating system (mainly represented by mitral cells) OB is lacking catshark Scyliorhinus canicula, fish. Using immunohistochemistry situ hybridization techniques, we have found that, previously to appearance primordium (OP), proliferating expressing Pax6 with hallmarks progenitor radial glia were located ventrolateral pallial ventricular zone. Later development, when OP recognizable, stream Pax6-positive observed zone OP, where cell (ScTbr2, ScNeuroD, Tbr1) are expressed. these became expressed layered-like structure ScVglut1, marker cells, also present. Our data suggest that related specification/differentiation telencephalon has been conserved throughout evolution vertebrates. These results, combination studies concerning GABAergic neurogenesis sharks, evidenced sharks shares similarities timing programs development.