Study of the glial cytoarchitecture of the developing olfactory bulb of a shark using immunochemical markers of radial glia

• DOI: 10.1007/s00429-021-02448-9
• Publication Date: 2022-01-07T19:03:11Z
• Authors: A. Docampo-Seara; E. Candal; M. A. Rodríguez
• Keywords: Olfactory ensheathing glia; Olfactory nerve; Neuroglia; Olfactory marker protein

During development of the olfactory bulb (OB), glial cells play key roles in axonal guiding/targeting, glomerular formation and synaptic plasticity. Studies mammals have shown that radial peripheral glia (olfactory ensheathing cells, OECs) are involved OB. Most studies about OB were carried out mammals, but data lacking most non-mammalian vertebrates. In present work, we studied system cartilaginous fish Scyliorhinus canicula (catshark) using antibodies against markers, such as fibrillary acidic protein (GFAP), brain lipid-binding (BLBP), glutamine synthase (GS). These markers expressed with morphology lining ventricle embryos this expression continues ependymal (tanycytes) early juveniles. Astrocyte-like also observed granular layer surrounding glomeruli. Numerous GS-positive primary pathway embryos. developmental stages analysed, nerve regions higher GFAP, BLBP GS immuno-reactivity. addition, numerous BLBP-expressing (a marker mammalian showing proliferative activity layer. Our findings suggest central origin coexist catshark results open path for future differential during embryonic adulthood.