Predictive factors for surgical treatment in preterm neonates with necrotizing enterocolitis: a multicenter case-control study

• DOI: 10.1007/s00431-020-03892-1
• Publication Date: 2020-12-02T23:02:34Z
• Authors: Sofia el Manouni ...; Hendrik J. Niemarkt; Joep P. M. Derikx; Daniel J. C. Berk...; Andrea E. Ballón; Margot de Graaf; Willem P. de Boode; Veerle Cossey; Christian V. Hulz...; Anton H. van Kaam; Boris W. Kramer; Richard A. van Li...; Daniel C. Vijlbrief; Mirjam M. van Wei...; Marc A. Benninga; Nanne K. H. de Boer; Tim G. J. de Meij
• Keywords: Necrotizing Enterocolitis; Univariate analysis; Enterocolitis

Abstract Necrotizing enterocolitis (NEC) is one of the most common and lethal gastrointestinal diseases in preterm infants. Early recognition infants need for surgical intervention might enable early intervention. In this multicenter case-control study, performed nine neonatal intensive care units, born (< 30 weeks gestation) diagnosed with NEC (stage ≥ IIA) between October 2014 August 2017 were divided into two groups: (1) medical (conservative treatment) (2) (sNEC). Perinatal, clinical, laboratory parameters collected daily up to clinical onset NEC. Univariate multivariate logistic regression analyses applied identify potential predictors sNEC. total, 73 (41 32 NEC) included. A low gestational age ( p value, adjusted odds ratio [95%CI]; 0.001, 0.91 [0.86–0.96]), no maternal corticosteroid administration (0.025, 0.19 [0.04–0.82]), (0.003, 0.85 [0.77–0.95]), serum bicarbonate (0.009, [0.76–0.96]), a hemodynamically significant patent ductus arteriosus which ibuprofen was administered 7.60 [2.03–28.47]) identified as independent risk factors Conclusions : Our findings may support clinician increased sNEC, facilitate decisive management consequently could result improved prognosis. What Known: • 27–52% NEC, indicated during its disease course. Absolute indication bowel perforation, whereas fixed loop or deterioration highly suggestive perforation necrosi, relative indication. New: Lower age, onset, corticosteroids are Low 3 days prior predict