The association between clinical and biochemical characteristics of late-onset sepsis and bronchopulmonary dysplasia in preterm infants

• DOI: 10.1007/s00431-021-03981-9
• Publication Date: 2021-02-25T05:24:57Z
• Authors: Melania E. Ebrahimi; Michelle Romijn; Roos J. S. Vliege...; Douwe H. Visser; Anton H. van Kaam; Wes Onland
• Keywords: Bronchopulmonary Dysplasia

Abstract Studies in preterm infants have shown an association between late-onset sepsis (LOS) and the development of bronchopulmonary dysplasia (BPD). It is unknown whether clinical or biochemical characteristics during modulate risk for BPD. This single-center retrospective cohort study included all patients with a gestational age < 30 weeks, born 2009 2015, whom empiric antimicrobial treatment was initiated > 72 h after birth continued at least 5 days, independent on microbiological results. The LOS BPD survivors were assessed multivariate logistic regression analysis adjusted early-onset sepsis, small age, age. Of 756 admitted infants, 256 (mean GA: 27.0 weeks; birthweight: 924 grams) had one episode, 79 (30.9%) developed Analyses showed that only need duration mechanical ventilation independently associated increased (adjusted OR 2.62, 95% CI 1.38, 4.96, p value 0.003, 1.004, 1.00, 1.007, 0.045, respectively). Conclusion: During LOS, are developing infants. What Known: • Premature diagnosed higher mainly positive blood culture New: investigates dysplasia.