Neonatal mortality and morbidity in Down syndrome in the time of prenatal aneuploidy testing: a retrospective cohort study
ANOMALIES
Heart Defects, Congenital
Down syndrome
Hypertension, Pulmonary
Neonatal morbidity
INFANTS
CHILDREN
Prenatal aneuploidy screening
DIAGNOSIS
Pediatrics
Persistent pulmonary hypertension of the neonate
03 medical and health sciences
0302 clinical medicine
Pregnancy
Infant Mortality
Humans
Neonatal mortality
Retrospective Studies
Science & Technology
BORN
Research
Incidence
Infant, Newborn
Infant
Aneuploidy
PERSISTENT PULMONARY-HYPERTENSION
PREVALENCE
3. Good health
CONGENITAL HEART-DISEASE
Congenital defects
Female
Down Syndrome
Life Sciences & Biomedicine
DOI:
10.1007/s00431-022-04686-3
Publication Date:
2022-11-09T08:04:45Z
AUTHORS (10)
ABSTRACT
Abstract The total uptake of prenatal aneuploidy screening for Down syndrome (DS) is increasing worldwide. As a result diagnosis DS and subsequent termination pregnancy, livebirth prevalence decreasing. aim this study to explore the impact an on neonatal mortality morbidity in DS. This retrospective cohort 253 neonates with born between 2012 2018 that were seen at outpatient clinic five hospitals Netherlands. medical files reviewed maternal characteristics morbidities. Dutch national birth registry (Perined) provided numbers results interpreted context other published studies. Neonatal remained stable, ranging from 1.4 3.6%. A congenital heart defect (CHD) was found 138 251 (55.0%) atrial septal defect, atrioventricular ventricular being most common. type CHD did not change over time. Gastro-intestinal defects present 22 252 (8.7%), duodenal atresia as reported anomaly. Persistent pulmonary hypertension neonate (PPHN) 31 infants (12.4%). Conclusions : Although increased, appears be stable. An increased incidence PPHN found. What Known: • New: persistent
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CITATIONS (2)
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