Hyponatremia and other potential markers of ultrasound abnormalities after a first febrile urinary tract infection in children

• DOI: 10.1007/s00431-023-05149-z
• Publication Date: 2023-08-16T23:02:35Z
• Authors: Isabel González-B...; Guillermo Barbas ...; Leire García Suarez; Rosario López López; Paula García Sánchez; Patricia Bote Gascón; Cristina Calvo
• Keywords: Febrile urinary tract infection; Risk Factors; Research; Urinary tract malformations; Urinary Tract Infections; Humans; Infant; Bacteremia; Marker; Child; 3. Good health; Hyponatremia; Retrospective Studies

Abstract Urinary tract infections are the initial manifestation in 30% of urinary malformations. Identifying these patients, who could benefit from a specific treatment, is still challenging. Hyponatremia during infection has been proposed as malformation marker. We evaluate prevalence hyponatremia febrile and its association with subjacent performed retrospective study healthy patients under 16 years, diagnosed first episode infection, had undergone blood testing acute at least one renal ultrasound follow-up (January 2014-November 2020). was defined (serum sodium ≤ 130 mEq/L). According to imaging findings, we classified into three groups: normal kidney ultrasound, mild pelviectasis, significant malformation. logistic regression models identify independent risk factors for pelviectasis. included 492 2.8% presented hyponatremia. identified 77%, pelviectasis 10.8%, 12% patients. found an between [OR 6.6 (CI95% 1.6–26.6)]. However, no The parameters that were associated malformations presenting non- E. coli C-reactive-protein levels over 80 mg/L, bacteremia. Conclusion : present imaging. does not indicate greater need complementary tests screen What Known: • children be marker guide approach. New: Around have Non-E. C-reactive protein bacteremia markers diagnostic tests, but (Na mEq/l) reliable