Evaluation of non-thyroidal illness syndrome in shock patients admitted to pediatric intensive care unit in a developing country

• DOI: 10.1007/s00431-023-05338-w
• Publication Date: 2023-11-23T05:01:44Z
• Authors: Ahmed El-Nawawy; Reham Abdel Halee...; Ahmed Khalil Abou...; Rehab Atef Rasheed; Omneya Magdy Omar
• Keywords: Illness severity; Euthyroid sick syndrome

During critical illness, children my experience various changes in their thyroid hormone levels. Such are termed non-thyroidal illness syndrome (NTI). The extent of change correlates with the severity and its outcomes critically ill patients. This study aimed to investigate correlation between shock derangement. prospective observational included forty patients aged one month five years who were admitted pediatric intensive care unit (PICU) shock. Thyroid function tests conducted on admission, after reversal, days later. NTI patterns observed 70% PIM2 score showed a significant negative T3 (r = - 0.353, p 0.026) FT3 levels admission 0.417, 0.007). Furthermore, continued exhibit correlations T4 0.444, 0.004), 0.329, 0.038), 0.355, 0.025), FT4 0.379, 0.016). Conclusion: underscores high prevalence PICU suggests monitoring for outcome prediction treatment guidance. Further research is needed optimize management children. What Known: • Non-thyroidal (NTIS) condition There has been limited children, existing studies have generated conflicting results regarding relationship hormones clinical cases sepsis septic New: revealed dynamic free triiodothyronine (FT3) during process reversal recovery experienced A was found Pediatric Index Mortality 2 (PIM2) several levels, including T4, FT3, reversal.