Atopic dermatitis in early life and pain at 10 years of age: An exploratory study

• DOI: 10.1007/s00431-024-05439-0
• Publication Date: 2024-02-24T16:02:27Z
• Authors: Vanessa Gorito; Maria Brandão; Inês Azevedo; André Moreira; Raquel Lucas
• Keywords: Atopy

Abstract Pain is a distinctive burden in atopic dermatitis and recognized as an important highly prevalent symptom. It unknown if the presence of disease may sensitize children to adverse pain profiles long term. We aimed assess impact early-life dermatitis-like symptoms on at 10 years age. used data from 1302 874 participants Generation XXI birth cohort evaluated 6 15 months, respectively, years. Atopy-like since birth, including dermatitis, were collected ages months by interviewing parents. history last 3 age was parents using structured questionnaires. computed relative risks (RR) respective 95% confidence intervals features according each atopic-like symptom months. Children whose reported had higher risk reporting any (RR 1.75 [1.15–2.66]) multisite pain, respectively 1.67 [1.18–2.37]) Conclusion : Atopic early life associated with 10, suggesting that potential for sensitization during first decade highlighting importance improving health care worth investigating. What Known: • disorders have been many non-atopic comorbidities, chronic pain. share common inflammatory pathways. Inflammation, injury skin scratching, fissures, intolerance irritants related can cause New: linked increased likelihood experiencing which suggests exploring worthwhile area investigation. Our proof-of-concept study highlights benefit studying management targets itching relieving quickly possible, avoiding long-term consequences process.