Natural products targeting the MAPK-signaling pathway in cancer: overview

• DOI: 10.1007/s00432-023-05572-7
• Publication Date: 2024-01-09T07:02:43Z
• Authors: Aiwen Shi; Li Liu; Shuang Li; Bin Qi
• Keywords: Natural product

Abstract Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these are elucidated, comprehensive information is provided on their potential use Methods Using PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant components”, “MAPK-signaling pathway”. We also screened compounds with well-defined structures targeting have effects. used Kingdraw software Adobe Photoshop to draw compound structural diagrams. Results A total 131 papers were searched, from which 85 selected. These clear treatment mainly related pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, juglone. components classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, quinones. Conclusions Certain MAPK inhibitors been clinical treatment. However, feedback has not promising because genomic instability, drug resistance, side Natural few effects, good medicinal efficacy, a wide range sources, individual heterogeneity biological activity, capable treating disease multiple targets. characteristics make drugs