Synchronous versus metachronous spinal metastasis: a comparative study of survival outcomes following neurosurgical treatment

• DOI: 10.1007/s00432-024-05657-x
• Publication Date: 2024-03-19T08:02:17Z
• Authors: Mohammed Banat; Anna-Laura Potthoff; Motaz Hamed; Valeri Borger; Jasmin E. Scorzin; Tim Lampmann; Harun Asoglu; Logman Khalafov; Frederic C. Schmeel; Daniel Paech; Alexander Radbruch; Louisa Nitsch; Johannes Weller; Ulrich Herrlinger; Marieta Toma; Gerrit H. Gielen; Hartmut Vatter; Matthias Schneider
• Keywords: Hematology

Abstract Purpose Patients with spinal metastases (SM) from solid neoplasms typically exhibit progression to an advanced cancer stage. Such can either develop concurrently existing diagnosis (termed metachronous SM) or emerge as the initial indication of undiagnosed malignancy (referred synchronous SM). The present study investigates prognostic implications compared SM following surgical resection. Methods From 2015 2020, a total 211 individuals underwent intervention for at our neuro-oncology facility. We conducted survival analysis starting date neurosurgical procedure, comparing those diagnosed against SM. Results predominant primary tumor types included lung (23%), prostate (21%), and breast (11.3%). Of participants, 97 (46%) had SM, while 114 (54%) median overall post-surgery was 13.5 months (95% confidence interval (CI) 6.1–15.8) 13 CI 7.7–14.2) ( p = 0.74). Conclusions Our findings suggest that timing (synchronous versus metachronous) does not significantly affect outcomes treatment These results support consideration procedures regardless temporal pattern manifestation.