Silencing PPP2R1A inhibits the progression of gastric cancer cells

• DOI: 10.1007/s00432-025-06177-y
• Publication Date: 2025-04-18T19:22:12Z
• Authors: Gengming Cheng; Laibijiang Wusiman; Dingding Song; Wenbin Zhang
• Keywords: PPP2R1A; Research; Cell migration and invasion; Cell apoptosis; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Gastric cancer; Cell proliferation; RC254-282

Abstract Background Protein phosphatase 2 regulatory subunit A alpha ( PPP2R1A ) is the most common scaffold protein in PP2A complex and has known tumor-suppressive functions. However, its role gastric cancer (GC) still unclear. This study aims to elucidate potential of biological functions GC. Methods The mutation status expression levels GC were assessed through bioinformatics analysis, correlation between patient survival rates was examined, functional network analyzed. Stable AGS MGC803 cell lines set up for overexpressing silencing . effects on proliferation, migration, invasion, apoptosis CCK-8 assays, scratch Transwell flow cytometry. Results significantly elevated samples P < 0.001) not caused by mutations > 0.05). Patients with high have a poorer 5-year rate 0.001). Silencing inhibits invasion cells while promoting 0.01). In contrast, overexpression does significant impact these cellular Conclusion oncogenic properties progression GC, knocking down can inhibit tumor cells. suggests that may serve as prognostic marker therapeutic target