Nuclear magnetic resonance-based lipid metabolite profiles for differentiation of patients with liver cirrhosis with and without hepatocellular carcinoma

• DOI: 10.1007/s00432-025-06178-x
• Publication Date: 2025-04-05T19:16:35Z
• Authors: Luigi Nardone; Marianna Alunni-F...; Regina Schinner; Sabine Weber; Julia Mayerle; Eric Schiffer; Sebastian de Jel; Max Seidensticker; Peter Malfertheiner; Jens Ricke
• Keywords: Metabolome; Liver Cancer

Hepatocellular carcinoma is frequently unrecognized in its early stage limiting the access to first therapeutic steps resulting a low cure rate. Therefore, an diagnosis crucial. In this scenario analysis of lipidome and metabolome emerged as promising tool for detection. Aim study was characterize metabolomic profiles novel markers hepatocellular carcinoma. Serum basal levels metabolites, isolated from cohort 90 patients (n = 30 stage; n advanced liver cirrhosis) were analysed using nuclear magnetic resonance spectroscopy platform. To assess predictive value profiles, we included imaging follow up control with cirrhosis. Significant differences observed individual parameters that total cholesterol, LDL HDL subclasses, Isoleucine, Valine, Triglycerides, Lactate, Alanine, Albumin, alpha Fetoprotein, Dimethylamine, Glycerol, Bilirubin cancer compared cirrhosis (p < 0.05). Furthermore, significant difference glycerol 0.05) decreasing trend dimethylamine cirrhotic who later developed HCC (16%, 5). Retrospective MRI revealed precursor lesions 3/5 patients, initially not classified due their size hemodynamic features. Nuclear based assessment lipidomic permit differentiation The data obtained suggests possible role serum