Cd271 mediates proliferation and differentiation of epidermal stem cells to support cutaneous burn wound healing

• DOI: 10.1007/s00441-017-2723-8
• Publication Date: 2017-11-17T21:46:10Z
• Authors: Min Zhang; Yongqian Cao; Xiaohong Li; Lizhi Hu; Sahbi Khaled Taieb; Xiaolong Zhu; Jing Zhang; Yongqiang Feng; Ran Zhao; Mingqing Wang; Wenjun Xue; Zhanjie Yang; Yibing Wang
• Keywords: Male; 0301 basic medicine; Wound Healing; Stem Cells; Cell Differentiation; Receptors, Nerve Growth Factor; 3. Good health; Mice, Inbred C57BL; 03 medical and health sciences; Cell Movement; Animals; Epidermis; Receptor, trkA; Burns; Cell Proliferation

Burn wounds can significantly reduce the quality of life of patients with respect to their physiology and psychology and can even threaten their lives. Many treatments have been proposed, including stem cell therapy but no effective method can as yet cure such damage. Our study highlights the role of Cd271 in epidermal stem cells (eSC) during the healing of burn wounds. The expression of Cd271 increases together with burn wound healing. Injection of Cd271-over-expressing eSC into wounds promotes the healing rate in a mouse burn model. Over-expression of Cd271 enhances the abilities of eSC with regard to their differentiation, proliferation and migration and even their resistance to apoptosis in vitro. These results are in accordance with a hypothesis suggesting that Cd271 promotes the healing of skin burn wounds by improving the potential of eSC for differentiation, proliferation and migration. Our findings shed light on the role of Cd271 in wound healing and may provide new therapeutic approaches for curing burn wounds of the skin.