Immunolocalization of leptin and leptin receptor in colorectal mucosa of ulcerative colitis, Crohn’s disease and control subjects with no inflammatory bowel disease

• DOI: 10.1007/s00441-020-03297-4
• Publication Date: 2020-11-07T15:02:44Z
• Authors: Flavia Merigo; Alessandro Brando...; Sonia Facchin; Federico Boschi; Marzia Di Chio; Edoardo Savarino; Renata D’Incà; Giacomo Carlo Stu...; Andrea Sbarbati
• Keywords: Lamina propria; Leptin receptor; Intestinal mucosa

The expression of leptin and receptor (Ob-R) has been partially elucidated in colon patients with inflammatory bowel diseases (IBDs), even though is involved angiogenesis inflammation. We previously reported overexpression GLUT5 fructose transporter, aberrant clusters lymphatic vessels lamina propria IBD controls. Here, we examine Ob-R the same biopsies. Specimens were obtained from ulcerative colitis (UC), Crohn's disease (CD) controls who underwent screening for colorectal cancer, follow-up after polypectomy or a history lower gastrointestinal symptoms. Immunohistochemistry revealed apical basolateral membranes short epithelial portions, on pole cells. Leptin also identified structures cells scattered propria. In UC, significant correlation between was found all inflamed samples, beyond non-inflamed samples proximal tract, while CD, it distal samples. Most positive areas immunoreactive mucosa. A observed UC. Our findings suggest that there are different sites large intestine those do not reflect status mucosal co-localization and/or may indicate concomitance effects areas.