Urine interleukin-18 and cystatin-C as biomarkers of acute kidney injury in critically ill neonates

• DOI: 10.1007/s00467-011-2072-x
• Publication Date: 2012-01-07T09:49:56Z
• Authors: Yanhong Li; Chenlu Fu; Xiaofei Zhou; Zhihui Xiao; Xueming Zhu; Meifang Jin; Xiaozhong Li; Xing Feng
• Keywords: Nephrology

Urinary interleukin-18 and cystatin-C are suggested to be biomarkers for predicting acute kidney injury (AKI). The aims of this study examine whether the urinary concentrations vary with gestational age other factors in non-AKI control neonates, determine can predict AKI development non-septic critically ill independently potential confounders. We enrolled 62 neonates. Urine was collected every 48–72 h during first 10 days life. concentration cystatin-C, but not interleukin-18, decreased increasing body weight, postnatal Both were associated AKI, even after controlling age, birth gender, Apgar score neonatal physiology had odds ratios 2.27 2.07, achieved area under-the-receiver-operating-characteristic curve 0.72 0.92, respectively, AKI. may decrease renal maturity. predictive