Prevalence of herpesviruses at onset of idiopathic nephrotic syndrome

• DOI: 10.1007/s00467-014-2860-1
• Publication Date: 2014-06-04T19:12:58Z
• Authors: Claire Dossier; Anne-Laure Sellie...; Alexandra Rousseau; Yanne Michel; Agnès Gautheret-D...; Mariana Englender; Fouad Madhi; Marina Charbit; Tim Ulinski; Tabassome Simon; Evelyne Jacqz-Aig...; Georges Deschênes
• Keywords: Male; Nephrotic Syndrome; Adolescent; [SDV]Life Sciences [q-bio]; MESH: Herpesviridae Infections; 03 medical and health sciences; 0302 clinical medicine; MESH: Child; Prevalence; Humans; Child; MESH: Prevalence; MESH: Adolescent; MESH: Humans; MESH: Child, Preschool; Infant; Herpesviridae Infections; MESH: Case-Control Studies; MESH: Infant; MESH: Male; MESH: DNA, Viral; 3. Good health; [SDV] Life Sciences [q-bio]; Case-Control Studies; Child, Preschool; DNA, Viral; Female; MESH: Nephrotic Syndrome; MESH: Female

Idiopathic nephrotic syndrome (INS) is likely a primary immune disorder, but viruses might also be involved in the mechanisms of the disease. Here, we investigate the link between herpesvirus infection and the first manifestation of INS in children.A prospective, multicentre, and population-based case-control study called NEPHROVIR included 164 patients, aged 6 months to 15 years old, newly diagnosed with INS, and 233 controls matched for gender, age, and period of sample. The analysis was done on 124 patients and 196 controls. Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus-6 (HHV-6), and human herpesvirus-7 (HHV-7) DNA prevalence at diagnosis were assessed from whole peripheral blood samples, as well as EBV and CMV viral load and seroprevalence.EBV DNA was significantly more prevalent in cases than in controls (50.8 vs 29.1 %; OR = 2.6; p = 0.0002), with no difference in viral load. A significant difference was also found for CMV (11.3 vs 3.6 %; p = 0.02) and HHV-7 (83 vs 72 %; p = 0.02) DNA prevalence between cases and controls. There were significantly more EBV and CMV recent infections or reactivations based on VCA-IgM and CMV IgM in cases than controls, while there were no differences in IgG seroprevalence.The prevalence of positive EBV DNA detection and recent infection or reactivation is higher in children at onset of INS compared to a population matched for age, gender, and time of sampling.