Changes in the health-related quality of life and social reintegration status after lung transplantation following hematopoietic stem cell transplantation

• DOI: 10.1007/s00520-021-06592-0
• Publication Date: 2021-10-05T17:07:28Z
• Authors: Ryota Hamada; Yohei Oshima; Susumu Sato; Yuji Yoshioka; Manabu Nankaku; Tadakazu Kondo; Toyofumi F. Chen-...; Ryosuke Ikeguchi; Daisuke Nakajima; Hiroshi Date; Shuichi Matsuda
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Hematopoietic Stem Cell Transplantation; Quality of Life; Humans; Transplantation, Homologous; Prospective Studies; Lung Transplantation; 3. Good health

Late-onset non-infectious pulmonary complications (LONIPCs) after allogeneic hematopoietic stem cell transplantation are fatal; however, lung transplantation might achieve good survival. Nevertheless, improving the health-related quality of life (HRQoL) is still a major concern. This study aimed to investigate, in detail, the recovery in HRQoL and social reintegration status after lung transplantation in patients with LONIPC after allo-HSCT.This prospective cohort study involving 18 patients examined changes in the health and social reintegration status after lung transplantation following LONIPC.Physical function and HRQoL were lowest before lung transplantation. Two years after lung transplantation, the dyspnea scores and performance status improved. Most patients had made a successful return to society, and patients who achieved social reintegration were significantly younger and had a good performance status. However, their Physical Functioning score and Physical Component Summary did not show significant improvement after lung transplantation. Moreover, recipients who were unemployed before lung transplantation were likely to remain unemployed and continued to show poor HRQoL.These results showed poor recovery of HRQoL, especially in terms of physical function, and the likelihood of failure to reintegrate into society within 2 years after lung transplantation. It is necessary to consider long-term follow-up and physical training to improve social reintegration and HRQoL.