Perturbations in the neuroactive ligand-receptor interaction and renin angiotensin system pathways are associated with cancer-related cognitive impairment

• DOI: 10.1007/s00520-025-09317-9
• Publication Date: 2025-03-06T09:04:06Z
• Authors: Raymond J. Chan; Adam Walker; Janette Vardy; Alexandre Chan; Kate Oppegaard; Yvette P. Conley; Steven M. Paul; Kord M. Kober; Carolyn Harris; Joosun Shin; Lisa Morse; Ritu Roy; Adam Olshen; Marilyn J. Hammer; Jon D. Levine; Christine Miaskowski

This study reports on the results from our data-driven approach that identified perturbations in neuroactive ligand-receptor interaction and renin-angiotensin system (RAS) pathways oncology patients with without self-reported cancer-related cognitive impairment (CRCI). In a sample of receiving chemotherapy (n = 1343), Attentional Function Index (AFI) was used to assess CRCI. Patients were grouped into low (AFI score < 5) versus high > 7.5) levels function. Gene expression analyses done using RNA-seq 185) microarray 158) technologies. Pathway impact analysis evaluate for biological associated The combined pathway revealed RAS significantly perturbed between AFI scores. Findings this suggest addition inflammatory pathways, numerous mechanisms may contribute underlying development and/or persistence