Exploring the real-world experience of abemaciclib treatment for HR +, HER2 − metastatic breast cancer—a qualitative analysis of the IMPACTOR study

• DOI: 10.1007/s00520-025-09444-3
• Publication Date: 2025-04-26T07:02:05Z
• Authors: Rachel Starkings; Helena Harder; Lesley Fallowfield; Valerie Shilling
• Keywords: Thematic Analysis; Pain medicine

Abstract Purpose The IMPACTOR study (IMPact of AbemaCiclib on patienTs’ rOles and Responsibilities–ISRCTN17281696) was developed to capture experiences women with MBC being treated abemaciclib in a real-world setting. primary aim explore changes quality life over time our secondary understand these detail via qualitative interviews, as presented here. Methods A singular interview offered participants who had expressed an interest at the point consent. These were all conducted remotely using semi-structured topic guide. Results Twenty interviews completed analysed framework approach thematic analysis. Eight themes developed—COVID-19, experience MBC, side effects, effect management, treatment information support, relationship impacts, impact daily life, finances employment. Conclusions It apparent that faced effects from but undertook steps manage much possible. Adaptations often led by belief about benefits remaining treatment. Adjustments ranged modifying routines carrying personal hygiene supplies when out public case diarrhoea. While this anticipated, other less well known variable clinical support available information. Family raised frequently, predominantly relation roles relationships. Themes work can be thought theories adherence, such common-sense self-regulation models, reflected both emotional cognitive coping strategies. Trial registration - ISRCTN17281696.