A multicenter case–control study of self-expanding metallic stent versus trans-anal colorectal tube for stage II/III non-right-sided obstructive colon cancer

• DOI: 10.1007/s00535-022-01952-x
• Publication Date: 2023-01-11T10:09:16Z
• Authors: Yusuke Okuda; Takaya Shimura; Konomu Uno; Tomonori Yamada; Takayuki Nukui; Takashi Mizushima; Yuya Takenaka; Keisuke Itoh; Yuki Inagaki; Takanori Ozeki; Kazuhiro Nagao; Masahide Ebi; Erika Uchida; Satoshi Nomura; Yu Nojiri; Shozo Togawa; Naomi Sugimura; Shigeki Fukusada; Hiroyasu Iwasaki; Takahito Katano; Hiromi Kataoka
• Keywords: Self Expandable Metallic Stents; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Case-Control Studies; Colonic Neoplasms; Humans; Stents; Neoplasm Recurrence, Local; Colorectal Neoplasms; Intestinal Obstruction; Retrospective Studies

Self-expanding metallic stent (SEMS) and trans-anal colorectal tube (TCT) are alternative treatments to conventional emergency surgery for non-right-sided obstructive colon cancer (NROCC). However, the one with better short- and long-term outcomes remains controversial. Thus, this multicenter case-control study aimed to analyze and compare SEMS and TCT for NROCC.Patients with stage II/III NROCC who underwent surgery between January 2010 and December 2019 at either of the eight selected Japanese affiliate hospitals were, retrospectively, reviewed. Baseline characteristics between the SEMS and TCT groups were adjusted by propensity score (PS) matching.Among 239 reviewed patients (SEMS: 76, TCT: 163), 180 were finally included in two well-balanced cohorts through PS: SEMS group (65 patients) and TCT group (115 patients). Technical success, clinical success, morbidity, and short-term mortality were not significantly different between the two groups. SEMS placement achieved significantly higher rates for primary resection/anastomosis without stoma (SEMS: 90.8% vs. TCT: 77.4%, p < 0.001) and laparoscopic surgery (SEMS: 64.6% vs. TCT: 43.5%, p < 0.001) than TCT placement. However, 5-year overall survival (SEMS: 83.7% vs. TCT: 86.4%; p = 0.822) and 5-year relapse-free survival (SEMS: 64.7% vs. TCT: 66.4%; p = 0.854) showed no significant differences between these groups.Both SEMS and TCT revealed similar long-term outcomes, but SEMS placement was better in achieving primary resection/anastomosis and laparoscopic surgery in patients with stage II/III NROCC.