Brain activity in response to food images in patients with irritable bowel syndrome and functional dyspepsia

• DOI: 10.1007/s00535-023-02031-5
• Publication Date: 2023-08-12T05:01:30Z
• Authors: Ryo Katsumata; Takayuki Hosokawa; Noriaki Manabe; Hitoshi Mori; Kenta Wani; Katsunori Ishii; Tomohiro Tanikawa; Noriyo Urata; Maki Ayaki; Ken Nishino; Takahisa Murao; Mitsuhiko Suehiro; Minoru Fujita; Miwa Kawanaka; Ken Haruma; Hirofumi Kawamoto; Toshihiro Takao; Tomoari Kamada
• Keywords: Original Article—Alimentary Tract; Irritable Bowel Syndrome; Food; Humans; Brain; Dyspepsia; 3. Good health; Pain Measurement

Abstract Background Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are caused exacerbated by consumption of fatty foods. However, no study has evaluated brain activity in response to food images patients with disorders gut–brain interaction (DGBI). This aimed compare preference when viewing between DGBI healthy controls. Methods FD IBS were diagnosed using the ROME IV criteria. Food was assessed a visual analog scale (VAS). Brain prefrontal cortex (PFC) investigated functional near-infrared spectroscopy (fNIRS). Results Forty-one enrolled, including 25 DGBI. The mean VAS scores for all foods (controls vs. IBS: 69.1 ± 3.3 54.8 3.8 62.8 3.7, p = 0.02), (78.1 5.4 43.4 6.3 64.7 6.1, < 0.01), lowest among groups. Patients had significantly higher left PFC than those controls (mean z -scores − 0.077 0.03 0.125 0.04 0.002 0.03, 0.001). Conclusions DGBI, particularly FD, disliked differed from that Increased confirmed.