Effect of interleukin 6 –174G>C gene polymorphism on opioid requirements after total hip replacement

• DOI: 10.1007/s00540-016-2167-4
• Publication Date: 2016-04-05T04:53:15Z
• Authors: Monika Białecka; Alina Jurewicz; Anna Machoy-Mokrz...; Mateusz Kurzawski; Katarzyna Leźnicka; Violetta Dziedziejko; Krzysztof Safranow; Marek Droździk; Andrzej Bohatyrewicz
• Keywords: Patient-Controlled Analgesia; Pain medicine

In recent years, increasing attention has been paid to the contribution of genetic factors variability in patient pain threshold and efficacy management. One genes implicated pathology treatment response is interleukin 6 (IL6). The aim present study was evaluate association between IL6 (rs1800795: –174G>C) opioid requirements patients after total hip replacement (THR). A 196 eligible for (126 women, 70 men) were subjected THR. THR procedure performed using spinal anaesthesia implementing routine peri-operative monitoring. After each individually observed, patient-specific chart dynamic changes perception recorded, five-level Verbal Rating Scale (VRS). multimodal analgesic defined by operating surgeons considering indications contraindications use different groups drugs (opioid non-opioid analgesics). Postoperative controlled patient-controlled analgesia method VRS during day-time, as well night-time nurse-controlled analgesia. All medication adjustments recorded individual files. case moderate intensity (VRS-assessed), a administered drug, high opioid. analysis relief therapy included information on applied, mode dosing (single or multiple), daily dose, route administration, drug refusal due absence day, i.e. day surgery recovery postoperative room (day 0), then from 1 6. Polymorphism rs1800795:G>C promoter region gene (–174G>C) determined PCR–RFLP method. carrying at least one –174G allele (GG homozygote GC heterozygote) opioids significantly more often days 0 (p = 0.0029), 3 0.019) 4 0.031) compared with CC homozygous patients. Those also required higher dose 0.029) 0.030). Multivariate demonstrated that presence an independent factor predisposing administration first 24 h [p 0.001, odds ratio (OR) 7.1, 95 % confidence interval (CI) 2.17–22.7], 0.01, OR 2.79, CI 1.25–6.26) 2.61, 1.17–5.79). G polymorphism found be frequent replacement.