Effects of oral carbohydrate with amino acid solution on the metabolic status of patients in the preoperative period: a randomized, prospective clinical trial

• DOI: 10.1007/s00540-016-2217-y
• Publication Date: 2016-07-20T05:37:34Z
• Authors: Rie Tsutsumi; Nami Kakuta; Takako Kadota; Takuro Oyama; Katsuyoshi Kume; Eisuke Hamaguchi; Noriko Niki; Katsuya Tanaka; Yasuo M. Tsutsumi
• Keywords: Pain medicine

Enhanced recovery after surgery is increasingly desired nowadays, and preoperative nutrient intake may be beneficial for this purpose. In study, we investigated whether the of carbohydrate with amino acid (ONS) solution can improve starvation status lipid catabolism before induction anesthesia. This randomized, prospective clinical trial included 24 patients who were divided into two groups under general anesthesia: a control group, comprising fasted their last meal day (permitted to drink only water), an ONS consumed 2 h surgery. Biochemical markers, respiratory quotient, psychosomatic scores assessed at initiation Compared group showed significantly lower serum free fatty levels [control group: 828 (729, 1004) µEq/L, 479 (408, 610) P = 0.0002, median (25th, 75th percentile)] total ketone bodies 119 (68, 440) µmol/L, 40 [27, 64] 0.037]. addition, analysis using Visual Analog Scale higher anxiety, hunger, thirst no differences in any other measure subjective well-being between groups. The results study suggest that improves Furthermore, it provide better mental health compared complete fasting.