Differentiation of benign and malignant vertebral fractures using a convolutional neural network to extract CT-based texture features

• DOI: 10.1007/s00586-023-07838-7
• Publication Date: 2023-07-04T11:38:19Z
• Authors: Sophia S. Goller; Sarah C. Foreman; Jon F. Rischewski; Jürgen Weißinger; Anna-Sophia Dietrich; David Schinz; Robert Stahl; Johanna Luitjens; Sebastian Siller; Vanessa F. Schmidt; Bernd Erber; Jens Ricke; Thomas Liebig; Jan S. Kirschke; Michael Dieckmeyer; Alexandra S. Gersing
• Keywords: Humans; Spinal Fractures; 610 Medicine & health; Original Article ; Automated segmentation ; Texture analysis ; Computed tomography ; Bone microstructure ; Convolutional neural network ; Medical and Health Sciences ; Information and Computing Sciences; Neural Networks, Computer; Tomography, X-Ray Computed; Spine; Osteoporotic Fractures; 3. Good health; ddc:

Abstract Purpose To assess the diagnostic performance of three-dimensional (3D) CT-based texture features (TFs) using a convolutional neural network (CNN)-based framework to differentiate benign (osteoporotic) and malignant vertebral fractures (VFs).

Methods A total of 409 patients who underwent routine thoracolumbar spine CT at two institutions were included. VFs were categorized as benign or malignant using either biopsy or imaging follow-up of at least three months as standard of reference. Automated detection, labelling, and segmentation of the vertebrae were performed using a CNN-based framework (https://anduin.bonescreen.de). Eight TFs were extracted: Varianceglobal, Skewnessglobal, energy, entropy, short-run emphasis (SRE), long-run emphasis (LRE), run-length non-uniformity (RLN), and run percentage (RP). Multivariate regression models adjusted for age and sex were used to compare TFs between benign and malignant VFs.

Results Skewnessglobal showed a significant difference between the two groups when analyzing fractured vertebrae from T1 to L6 (benign fracture group: 0.70 [0.64–0.76]; malignant fracture group: 0.59 [0.56–0.63]; and p = 0.017), suggesting a higher skewness in benign VFs compared to malignant VFs.

Conclusion Three-dimensional CT-based global TF skewness assessed using a CNN-based framework showed significant difference between benign and malignant thoracolumbar VFs and may therefore contribute to the clinical diagnostic work-up of patients with VFs.