Serum periostin levels correlate with severity of intervertebral disc degeneration

• DOI: 10.1007/s00586-024-08162-4
• Publication Date: 2024-02-10T12:02:13Z
• Authors: Tadatsugu Morimoto; Takaomi Kobayashi; Hayato Ito; Masatsugu Tsukamoto; Tomohito Yoshihara; Hirohito Hirata; Koji Otani; Kenji Izuhara; Satoshi Nunomura; Masaaki Mawatari
• Keywords: Male; Adult; Lumbar Vertebrae; Intervertebral Disc Degeneration; Middle Aged; Severity of Illness Index; Periostin; Humans; Female; Cell Adhesion Molecules; Biomarkers; Intervertebral Disc Displacement; Retrospective Studies; Aged

Periostin, an extracellular matrix protein closely related to mechanical stress, inflammation, and ageing, has been implicated in intervertebral disc degeneration (IVDD) in basic research. However, it has not been examined in clinical cases. This study aimed to evaluate the association between IVDD severity and serum periostin concentration as well as to analyse potential associations between IVDD and clinical and demographic factors.This retrospective cohort study included 198 patients who underwent lumbar disc herniation and lumbar canal stenosis between January 2020 and December 2022. The severity of IVDD was evaluated using the Pfirrmann grading, whereas serum periostin levels were measured using ELISA kits. Clinical demographics, including age, sex, body mass index, comorbidities, psoas muscle index, and spinal disease, were also recorded.This study demonstrated a significant correlation between high serum periostin levels and IVDD severity, as indicated by a high cumulative Pfirrmann score. Serum periostin levels were identified as an independent risk factor for IVDD in a multivariate regression model. Correlation analysis showed a correlation between periostin levels and Pfirrmann grade at each lumbar level (ρ = 0.458-0.550, p < 0.001) and a strong correlation with cumulative Pfirrmann score (ρ = 0.690, p < 0.001).The higher the serum periostin level, the higher the cumulative Pfirrmann score. Multivariate analysis showed that serum periostin was an independent risk factor for IVDD. Periostin levels may be a clinically suitable and useful biomarker for diagnosing IVDD, estimating disease progression and activity, providing prognostic information, and evaluating treatment options.