Remnant cholesterol for the detection of glucose metabolic states in patients with coronary heart disease angina pectoris

• DOI: 10.1007/s00592-022-01935-7
• Publication Date: 2022-07-23T22:02:41Z
• Authors: Yang Wang; Yijia Liu; Rongrong Yang; Zhu Li; Jinyu Su; Tong Yang; Mei Ma; Guangwei Pan; Xianliang Wang; Lin Li; Chunquan Yu
• Keywords: Blood Glucose; Glycated Hemoglobin; Male; Coronary Disease; Middle Aged; Angina Pectoris; 3. Good health; Prediabetic State; 03 medical and health sciences; Cholesterol; Glucose; 0302 clinical medicine; Risk Factors; Humans; Female; Aged

This study aimed to evaluate the relationship between remnant cholesterol (RC) and glucose metabolic states in coronary heart disease (CHD) patients with angina pectoris.This study collected data from 11,557 CHD patients with angina pectoris aged 35-75 years in Tianjin, China. Participants were divided into normal glucose regulation (NGR), prediabetes (Pre-DM) and diabetes mellitus (DM) groups according to glucose metabolic states. Linear regression analysis was used to explore the relationship between glucose metabolism [fasting blood glucose (FBG) and glycated hemoglobin (HbA1c)] and RC levels. Logistic regression was performed to analyze the relationship between RC levels and glucose metabolic states.Among all participants, 5883 (50.9%) had a DM state and 4034 (34.9%) had a Pre-DM state. FBG levels and HbA1c levels were positively related with RC in all patients (P < 0.001). NGR was used as a reference, multi-adjusted model showing that RC level was significantly associated with Pre-DM [Odds ratio (OR): 1.37; 95% confidence interval (CI) 1.19-1.56; P < 0.001] and DM state (OR:1.47; 95% CI 1.29-1.67; P < 0.001). When considering RC as categorical variables (tertiles), using T1 as a reference, T3 had the strongest relationship between RC levels and Pre-DM and DM state in univariate model and multivariate model. In the stratified analyses, the association between RC levels and pre-DM and DM in women was higher than that in men, and the elderly patients was higher than in the middle-aged patients.The study demonstrated a significant association between RC levels and pre-DM and DM state among CHD patients with angina pectoris, and the relationship was stronger in women and elderly patients.