Early renal dysfunction after temporary ileostomy construction

• DOI: 10.1007/s00595-019-01938-y
• Publication Date: 2019-12-21T10:02:43Z
• Authors: Mizunori Yaegashi; Koki Otsuka; Toshimoto Kimura; Teppei Matsuo; Hitoshi Fujii; Kei Sato; Kiyoharu Takashimizu; Tomoki Hatanaka; Toru Yoshida; Chihiro Tono; Akira Sasaki
• Keywords: Male; Time Factors; Ileostomy; Rectal Neoplasms; Rectum; Chemoradiotherapy, Adjuvant; Middle Aged; Kidney; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Chemotherapy, Adjuvant; Risk Factors; Case-Control Studies; Preoperative Care; Humans; Female; Digestive System Surgical Procedures; Aged; Glomerular Filtration Rate

Loop ileostomy is often used to prevent complications after colorectal surgery, but it has been reported to cause renal impairment. This study aimed to evaluate the changes in the renal function after ileostomy and to compare these with the renal function after low anterior resection without ileostomy (low-ANT).The subjects included 58 patients who underwent ileostomy construction and closure for rectal cancer. The estimated glomerular filtration rate (eGFR) was calculated at specific time points after the index surgery. In addition, we conducted a case-matched study on 147 patients who underwent low-ANT.The eGFR was significantly lower at 1 month after ileostomy than at the time of ileostomy construction (78.8 vs. 84.0, p < 0.0001) and did not improve after ileostomy closure. The only risk factor for a reduced eGFR was preoperative chemotherapy or chemoradiotherapy. In the case-matched study, 36 patients were allocated for each of the two groups. The number of ileostomy patients with a reduced eGFR was significantly increased 1 month after the index surgery (p = 0.005).The eGFR began to decrease at one month after ileostomy construction and did not improve after ileostomy closure.