Assessment of non-invasive ICP during CSF infusion test: an approach with transcranial Doppler

• DOI: 10.1007/s00701-015-2661-8
• Publication Date: 2015-12-23T02:11:34Z
• Authors: D. Cardim; M. Czosnyka; J. Donnelly; C. Robba; B. C. T. Cabella; X. Liu; M. T. Cabeleira; P. Smielewsky; C. Haubrich; M. R. Garnett; J. D. Pickard; Z. Czosnyka
• Keywords: Transcranial Doppler; Pulsatility index

This study aimed to compare four non-invasive intracranial pressure (nICP) methods in a prospective cohort of hydrocephalus patients whose cerebrospinal fluid dynamics was investigated using infusion tests involving controllable test-rise ICP. Cerebral blood flow velocity (FV), ICP and arterial (ABP) were recorded 53 diagnosed for hydrocephalus. Non-invasive based on: (1) interaction between FV ABP black-box model (nICP_BB); (2) diastolic (nICP_FVd); (3) critical closing (nICP_CrCP); (4) transcranial Doppler-derived pulsatility index (nICP_PI). Correlation rise (∆ICP) ∆nICP averaged correlations changes time nICP during test investigated. From baseline plateau, all estimators increased significantly. Correlations ∆ICP better represented by nICP_PI nICP_BB: 0.45 0.30 (p < 0.05). nICP_FVd nICP_CrCP presented non-significant correlations: −0.17 = 0.21), 0.21 0.13). For individual nICP_PI, nICP_BB similar with ICP: 0.39 ± 0.40, 0.43 0.35 0.41 respectively. However, weaker correlation (R 0.29 0.24). Out the methods, one best performance predicting test, followed nICP_BB. Unreliable shown nICP_CrCP. Changes observed expressed values only moderate correlations.