Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson’s disease drug, rasagiline compared with selegiline, in the rat midbrain
Proteomics
0301 basic medicine
Cell Survival
Neurogenesis
Nerve Tissue Proteins
Parkinson Disease
Genomics
Rats
3. Good health
Antiparkinson Agents
Substantia Nigra
03 medical and health sciences
Neuroprotective Agents
0302 clinical medicine
Indans
Selegiline
Animals
Female
Nerve Growth Factors
Rats, Wistar
Biomarkers
Signal Transduction
DOI:
10.1007/s00702-009-0225-x
Publication Date:
2009-04-24T09:40:18Z
AUTHORS (5)
ABSTRACT
The novel anti-Parkinson's disease (PD) drug, rasagiline (N-propargyl-1-(R)-aminoindan), is a second generation of irreversible selective inhibitor of monoamine oxidase-B follows selegiline. In light of the recent large clinical study (phase III ADAGIO) reporting benefits in PD patients, it has been suggested that rasagiline could be the first PD treatment to receive the label neuroprotective "disease-modifying" drug. Indeed, rasagiline has been shown to have a broad neuroprotective activity against a variety of neurotoxins in preclinical models of neurodegenerative diseases and in cultured neuronal cells. In the present study, we have investigated the status of various molecular and biochemical markers in the rat midbrain following chronic treatments with rasagiline and selegiline, using proteomic and genomic analyses. Our findings demonstrated significant molecular changes induced by both drugs, at the protein and transcriptional levels, associated with neuronal differentiation, cell survival and death pathways, metabolism/oxidation stress, signaling system, and biomarkers of neurodegenerative disorders, which may be reflected in the clinical studies.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (92)
CITATIONS (22)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....