Alterations in regional homogeneity of resting-state brain activity in fatigue of Parkinson’s disease
Male
0301 basic medicine
Rest
Statistics as Topic
Brain
Parkinson Disease
Middle Aged
Mental Status and Dementia Tests
Magnetic Resonance Imaging
Severity of Illness Index
Statistics, Nonparametric
3. Good health
Oxygen
03 medical and health sciences
Cross-Sectional Studies
Case-Control Studies
Image Processing, Computer-Assisted
Humans
Female
Fatigue
Aged
DOI:
10.1007/s00702-017-1748-1
Publication Date:
2017-06-24T03:58:00Z
AUTHORS (8)
ABSTRACT
Fatigue is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of fatigue in PD remain uncertain. In this cross-sectional study, our aim was to study the change of the local brain function in PD patients with fatigue. Among 49 patients with PD, 17 of them had fatigue and the remaining 32 patients without fatigue, and 25 age- and gender-matched healthy controls were enrolled. All subjects were evaluated with Fatigue Severity Scale (FSS) and had a resting-state functional magnetic resonance imaging (rs-fMRI) scan. The fMRI images were analyzed using regional homogeneity (ReHo) to study the change of the local brain function. ReHo analysis controlling for gray matter volume, age, gender, and education showed decreased ReHo in the left anterior cingulate cortex (ACC) and the right superior frontal gyrus (dorsolateral part), and increased ReHo in the left postcentral gyrus and the right inferior frontal gyrus (orbital and triangular part), compared PD-F with PD-NF; In PD patients, the regional activity in the left ACC and the right superior frontal gyrus (dorsolateral part) was negatively correlated with the FSS scores, while that in the left postcentral gyrus, the right inferior frontal gyrus (orbital and triangular part) was positively correlated with the FSS scores. This study demonstrates that brain areas including frontal, postcentral and ACC regions indicative of sensory, motor, and cognitive systems are involved in fatigue in PD patients.
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