Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond

• DOI: 10.1007/s00702-020-02155-5
• Publication Date: 2020-02-18T09:02:50Z
• Authors: Oxana Kapitansky; Eliezer Giladi; Iman Jaljuli; Stefan Bereswill; Markus M. Heimesaat; Illana Gozes
• Keywords: Nap; Prevotella

Abstract Activity-dependent neuroprotective protein (ADNP) and its snippet NAP (drug candidate CP201) regulate synapse formation cognitive as well behavioral functions, in part, through microtubule interaction. Given potential interactions between the microbiome brain function, we now investigated effects of ADNP-deficient genotype, mimicking ADNP syndrome on microbiota composition Adnp +/– mouse model. We have discovered a surprising robust sexually dichotomized genotype effect correction by (CP201) follows. Most commensal bacterial tested were affected corrected treatment male sex-dependent manner. The following list includes all groups tested—labeled bold are —genotype increased (decreased) NAP. (1) Eubacteriaceae (EubV3) , (2) Enterobacteriaceae (Entero), (3) Enterococcus genus (gEncocc), (4) Lactobacillus group (Lacto), (5) Bifidobacterium (BIF) (6) Bacteroides/Prevotella species (Bac), (7) Clostridium coccoides (Coer), (8) leptum (Cluster IV, sgClep), (9) Mouse intestinal Bacteroides (MIB). No similarities found males females regarding sex- genotype-dependent distributions. Furthermore, female associated decrease (contrasting increase) was observed (Lacto). Significant correlations specific loads open-field behavior social recognition behaviors. In summary, deficiency changes gut compositions, biomarker for beyond. Strikingly, rapidly detected treatment-dependent biomarkers within microbiota.