Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves

• DOI: 10.1007/s00705-007-1005-2
• Publication Date: 2007-06-12T13:14:55Z
• Authors: S. J. Park; G. Y. Kim; H. E. Choy; Y. J. Hong; L. J. Saif; J. H. Jeong; S. I. Park; H. H. Kim; S. K. Kim; S. S. Shin; M. I. Kang; K. O. Cho
• Keywords: Bovine coronavirus; Respiratory tract; Viral Shedding

Although winter dysentery (WD), which is caused by the bovine coronavirus (BCoV) characterized sudden onset of diarrhea in many adult cattle a herd, pathogenesis WD-BCoV not completely understood. In this study, colostrum-deprived calves were experimentally infected with Korean strain and examined for viremia, enteric nasal virus shedding as well viral antigen expression virus-associated lesions small large intestines upper lower respiratory tract from 1 to 8 days after an oral infection. The WD-BCoV-inoculated showed gradual villous atrophy intestine increase crypt depth intestine. WD-BCoV-infected animals epithelial damage turbinates, trachea lungs, interstitial pneumonia. was detected epithelium intestines, lungs. RNA serum post-inoculation day 3. These results show that has dual tropism induces pathological changes both digestive tracts calves. To our knowledge, first detailed report tropisms Comprehensive studies tissue BCoV might contribute increased understanding similar pneumoenteric CoV infections humans.