Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010
Adult
Male
0301 basic medicine
China
Molecular Epidemiology
0303 health sciences
Adolescent
Incidence
Molecular Sequence Data
Norovirus
Genetic Variation
Infant
Middle Aged
Gastroenteritis
3. Good health
Feces
03 medical and health sciences
Child, Preschool
Humans
Female
Child
Phylogeny
Aged
Caliciviridae Infections
DOI:
10.1007/s00705-012-1437-1
Publication Date:
2012-08-10T15:32:56Z
AUTHORS (10)
ABSTRACT
To study epidemiological features and genetic characteristics of noroviruses in children and adults with acute gastroenteritis, fecal specimens were collected in three hospitals from Jan. 2007 to May 2010 in Wuhan, China. Noroviruses were detected in 25.9 % (286/1103) and 24.6 % (202/822) of the specimens from children and adults, respectively, with genogroup II (GII) being predominant (99.2 %). The most frequent genotype among GII strains was GII.4 (2006b variant) (77.3 %) (72.0 % in children and 87.9 % in adults), followed by GII.3 (15.0 %) and GII.6 (3.4 %). Potential recombinant genotypes (polymerase/capsid) were detected in 51 GII strains (15.9 %), including the most frequent type, GII.12/GII.3 (28 strains), and GII.16/GII.2, detected for the first time in China, which were found in only children. The results indicated that genetically similar noroviruses were circulating among children and adults as a cause of gastroenteritis, except for some recombinant genotypes.
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