Molecular epidemiology of noroviruses in children and adults with acute gastroenteritis in Wuhan, China, 2007-2010

Adult Male 0301 basic medicine China Molecular Epidemiology 0303 health sciences Adolescent Incidence Molecular Sequence Data Norovirus Genetic Variation Infant Middle Aged Gastroenteritis 3. Good health Feces 03 medical and health sciences Child, Preschool Humans Female Child Phylogeny Aged Caliciviridae Infections
DOI: 10.1007/s00705-012-1437-1 Publication Date: 2012-08-10T15:32:56Z
ABSTRACT
To study epidemiological features and genetic characteristics of noroviruses in children and adults with acute gastroenteritis, fecal specimens were collected in three hospitals from Jan. 2007 to May 2010 in Wuhan, China. Noroviruses were detected in 25.9 % (286/1103) and 24.6 % (202/822) of the specimens from children and adults, respectively, with genogroup II (GII) being predominant (99.2 %). The most frequent genotype among GII strains was GII.4 (2006b variant) (77.3 %) (72.0 % in children and 87.9 % in adults), followed by GII.3 (15.0 %) and GII.6 (3.4 %). Potential recombinant genotypes (polymerase/capsid) were detected in 51 GII strains (15.9 %), including the most frequent type, GII.12/GII.3 (28 strains), and GII.16/GII.2, detected for the first time in China, which were found in only children. The results indicated that genetically similar noroviruses were circulating among children and adults as a cause of gastroenteritis, except for some recombinant genotypes.
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