Eco-friendly synthesis of amidochloroalkylnaphthols and its related oxazepinones with biological evaluation

• DOI: 10.1007/s00706-015-1536-2
• Publication Date: 2015-07-22T09:26:23Z
• Authors: Hanan A. Soliman; Ahmed Y. Mubarak; Ahmed El-Mekabaty; Hanem M. Awad; Saad S. Elmorsy
• Keywords: 01 natural sciences; 0104 chemical sciences

A general mild and efficient protocol for the synthesis of amidochloroalkylnaphthol libraries was achieved utilizing SiO2–ZnCl2 (silzic) as a reusable heterogeneous catalyst via Ritter-type reaction, through one-pot, three-component condensation of various aldehydes, chloroacetonitrile, and β-naphthol under solvent-free reaction conditions. The amidochloroalkylnaphthols were cyclized to its related oxazepinones, and their anticancer and antioxidant activities were studied.