Synthesis and antimicrobial activity evaluation of some novel water-soluble isatin-3-acylhydrazones

• DOI: 10.1007/s00706-017-2049-y
• Publication Date: 2017-12-05T14:45:54Z
• Authors: Andrei V. Bogdanov; Ilyuza F. Zaripova; Alexandra D. Volo...; Anastasia S. Stro...; Natalia V. Kulik; Sergey V. Bukharov; Julia K. Voronina; Ayrat R. Khamatga...; Vladimir F. Mironov
• Keywords: 01 natural sciences; 0104 chemical sciences

By acid-catalyzed reaction of substituted isatins with Girard’s reagent T, new water-soluble isatin-3-acylhydrazones were obtained with high yields. Their antimicrobial activity was evaluated. Selective activity against Gram-positive bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus Candida albicans 855–653 along with low hematoxicity was established.