Synthesis of fused 1,5-disubstituted tetrazoles via a one-pot Knoevenagel condensation/nucleophilic substitution/intramolecular/intermolecular [3 + 2] cycloaddition reaction

• DOI: 10.1007/s00706-017-2062-1
• Publication Date: 2017-12-01T09:26:48Z
• Authors: Afshin Sarvary; Faezeh Khosravi; Mohammad Ghanbari
• Keywords: Knoevenagel condensation; Substitution (logic)

An efficient synthesis of pyrrolo[1,2-d]tetrazole derivatives is achieved via one-pot Knoevenagel condensation, nucleophilic substitution, intramolecular and intermolecular cyclization reactions of α-bromoacetophenones, malononitrile, and sodium azide in EtOH as solvent in the presence of K2CO3. The products are formed in moderate yields.