Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions

• DOI: 10.1007/s00706-018-2174-2
• Publication Date: 2018-02-23T13:02:29Z
• Authors: Nader Ghaffari Kh...; Taraneh Mihankhah; Mohad Rafie Johan; Juan Joon Ching
• Keywords: 13. Climate action; TA Engineering (General). Civil engineering (General); QD Chemistry; 01 natural sciences; 7. Clean energy; 0104 chemical sciences

A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions.