Using pseudo amino acid composition to predict protein subcellular location: Approached with Lyapunov index, Bessel function, and Chebyshev filter

• DOI: 10.1007/s00726-005-0206-9
• Publication Date: 2005-05-27T12:06:12Z
• Authors: Y. Gao; S. Shao; X. Xiao; Y. Ding; Y. Huang; Z. Huang; K.-C. Chou
• Keywords: 0301 basic medicine; Protein Transport; 03 medical and health sciences; Proteins; Amino Acid Sequence; Models, Biological

With the avalanche of new protein sequences we are facing in the post-genomic era, it is vitally important to develop an automated method for fast and accurately determining the subcellular location of uncharacterized proteins. In this article, based on the concept of pseudo amino acid composition (Chou, K.C. Proteins: Structure, Function, and Genetics, 2001, 43: 246-255), three pseudo amino acid components are introduced via Lyapunov index, Bessel function, Chebyshev filter that can be more efficiently used to deal with the chaos and complexity in protein sequences, leading to a higher success rate in predicting protein subcellular location.