Selective modification of fluciclovine (18F) transport in prostate carcinoma xenografts

• DOI: 10.1007/s00726-018-2600-0
• Publication Date: 2018-06-15T13:35:20Z
• Authors: F. I. Tade; W. G. Wiles; G. Lu; B. Bilir; O. Akin-Akintayo; J. S. Lee; D. Patil; W. Yu; C. Ormenisan Gher...; B. Fei; C. S. Moreno; A. O. Osunkoya; E. J. Teoh; S. Oka; H. Okudaira; M. M. Goodman; D. M. Schuster
• Keywords: Isobutyric acid

We investigated if previously demonstrated inhibition of fluciclovine (18F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (± 5.4)% and 25.3 (± 5.2)% lower in BCH (n = 6) and MeAIB (n = 5) injected PC3 Luc xenografts, respectively, compared to saline-injected controls (n = 2). Partial inhibition of fluciclovine uptake by BCH and MeAIB can be demonstrated in vivo similar to previous in vitro modeling.