Morphological characterization of pulmonary microvascular disease in bronchopulmonary dysplasia caused by hyperoxia in newborn mice

• DOI: 10.1007/s00795-018-0182-2
• Publication Date: 2018-01-23T14:27:43Z
• Authors: Hidehiko Nakanishi; Shunichi Morikawa; Shuji Kitahara; Asuka Yoshii; Atsushi Uchiyama; Satoshi Kusuda; Taichi Ezaki
• Keywords: Mice, Inbred ICR; Hypertrophy, Right Ventricular; Hypertension, Pulmonary; Endothelial Cells; Hyperoxia; Pulmonary Artery; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; 0302 clinical medicine; Animals, Newborn; Microscopy, Electron, Transmission; Microvessels; Animals; Humans; Female; Endothelium, Vascular; Lung; Bronchopulmonary Dysplasia

AbstractBronchopulmonary dysplasia (BPD) is one of the most significant medical complications in preterm infants, and pulmonary microvascular injury is associated with the pathogenesis of BPD [1]. Furthermore, impairments of developing pulmonary vasculature may cause secondary pulmonary hypertension (PH), which contributes significantly to morbidity and mortality among preterm infants [2]. To characterize the mechanisms of pulmonary vascular disease resulting from BPD, we studied the ultrastructural changes affecting pulmonary microvasculature.