Trisomy 1 in a case of a missed abortion

• DOI: 10.1007/s10038-004-0164-1
• Publication Date: 2004-06-07T12:08:41Z
• Authors: Michio Banzai; Satoshi Sato; Hideo Matsuda; Hiroshi Kanasugi
• Keywords: Trisomy; Products of conception

Most chromosomal trisomies lead to miscarriages. In all trisomies, trisomy 1 is the most rare case. We herein present a patient who demonstrated a gestational sac and a yolk sac on transvaginal ultrasound. However, at 53 days of gestation, the pregnancy was lost with a diagnosis of a blighted ovum. A D&C was recommended and performed. A cytogenetic analysis from chorionic villi demonstrated a 47,XX,+1 chromosome complement in all 100 cells. Regarding full trisomy 1, there has only been one case report of a preembryo and two case reports in a clinically recognized pregnancy to date.